Home / Reports / Impact of breast cancer generics in Europe

Impact of breast cancer generics in Europe Posted 25/03/2016

Breast cancer generics can increase patient adherence and reduce healthcare budgets for European countries, according to a report by the Germany-based Institute for Healthcare and Social Research (IGES).

Breast cancer is the most common cancer in women both in the developed and less developed world. It is estimated that worldwide over 508,000 women died in 2011 due to breast cancer.

Hormone receptor-positive (HER+) breast cancer includes about two thirds of all breast cancer cases. For this indication, there are two main types of therapies: Selective Estrogen Receptor Modulators (SERMs), e.g. tamoxifen; and Aromatase Inhibitors (AI), e.g. anastrazole, letrozole and exemestane. Generics competition for SERM began in 1985, but for AI this only started in 2011. AI and tamoxifen have been found to be equivalent in terms of overall survival.

A study by Hershman et al. (2014) for patients in the US found that adherence was positively associated with generic AI use (odds ratio = 1.53, 95% CI = 1.22–1.91) compared with brand-name AI. The study also found that adherence was inversely associated with increased monthly co-payment. In addition, adherence was associated with a high annual income of more than US$100,000 per year.

When considering cost-effectiveness, a study of generic endocrine therapies in Germany yielded a decline of incremental cost per quality-of-life year (QALY) compared with tamoxifen ranging from almost 30% (with 25% price reduction) to 87–89% (with 75% price reduction).

In conclusion, breast cancer generics can increase patient adherence depending on co-payments and income, while also being cost-effective for governments and payers.

Related articles

Impact of antidepressant generics in Europe

Impact of hypertension generics in Europe

Impact of generics on European budgets

Generics market share in Europe

Generics reduce costs and increase access

Source:EGA

Permission granted to reproduce for personal and non-commercial use only. All other reproduction, copy or reprinting of all or part of any ‘Content’ found on this website is strictly prohibited without the prior consent of the publisher. Contact the publisher to obtain permission before redistributing.

Copyright – Unless otherwise stated all contents of this website are © 2016 Pro PharmaCommunications International. All Rights Reserved.

Comments (0)

Generics News Research General

more

Biosimilars News Research General

more